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http://ntur.lib.ntu.edu.tw/handle/246246/94765
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| Title: | A Novel Peptide Specifically Binding to Nasopharyngeal Carcinoma for Targeted Drug Delivery |
| Authors: | 李冬陽;吳漢忠;林欽塘
LEE, TONG-YOUNG;WU, HAN-CHUNG;LIN, CHIN -TARNG |
| Contributors: | 口腔生物研究所 |
| Keywords: | STERICALLY STABILIZED LIPOSOMES;PHAGE DISPLAY;SOLID TUMORS;MOUSE MODEL;THERAPEUTIC-EFFICACY;VESSEL LEAKINESS |
| Date: | 2004 |
| Issue Date: | 2008-12-29T05:56:46Z |
| Abstract: | Nasopharyngeal carcinoma (NPC) is a common cancer among Chinese living in southern China, Taiwan, and Singapore. The 5-year survival rate in the early stage of NPC has been reported as high as 90 to 95% with the use of radiotherapy, but in the advanced cases, even with the use of both chemotherapy and radiotherapy, the survival rate is still < 50%. To improve the survival rate, we identify a 12-mer peptide (L-peptide) specifically binding to NPC cells with a phage displayed random peptide library. The L-pliage and synthetic L-peptide bound to the tumor cell surfaces of most NPC cell lines and biopsy specimens, but not normal nasal mucosal cells, and the L-peptide-linked liposomes containing fluorescent substance (L-peptide-Lipo-HPTS) were capable of binding to and translocating across plasma membranes. L- Peptide-linked liposomes that carried doxorubicin (L-peptide -Lipo-Dox) caused marked cytotoxicity in NPC cells. In SCID mice bearing NPC xenografts, the L-phages specifically bound to the tumor mass, an effect that was inhibited by competition with synthetic L-peptide. In addition, the L- peptide-Lipo-Dox suppressed tumor growth better than Lipo- Dox. These results indicate that the novel L- peptide specifically binds NPC cells and is a good candidate for targeted drug delivery to NPC solid tumors. |
| Relation: | CANCER RESEARCH v.64 n.21 pp.8002-8008 |
| Appears in Collections: | [Grad. Inst. of Oral Biology] Periodical Articles
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