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http://ntur.lib.ntu.edu.tw/handle/246246/94571
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| Title: | Ganoderic Acid X, a Lanostanoid Triterpene, Inhibits Topoisomerases and Induces Apoptosis of Cancer Cells |
| Authors: | 方偉宏;蔡克嵩;林淑萍;甘魯生
FANG, WOEI-HORNG;TSAI, KEH-SUNG;LIN, SHWU-BIN;KAN, LOU-SING |
| Contributors: | 醫學檢驗暨生物技術學系 |
| Keywords: | Ganoderma triterpene;Ganoderic acid X;Topoisomerase inhibitor;Apoptosis |
| Date: | 2005 |
| Issue Date: | 2009-09-23T04:27:02Z |
| Abstract: | Lanostanoid triterpenes isolated from Ganoderma amboinense were found to inhibit the growth of numerous cancer cell lines, and some of them inhibited the activities of topoisomerases I and II?? in vitro. Among the bioactive isolates, one of the most potent triterpene was identified to be 3??-hydroxy-15??-acetoxy-lanosta-7,9(11),24-trien-26- oic acid, ganoderic acid X (GAX). Treatment of human hepatoma HuH-7 cells with GAX caused immediate inhibition of DNA synthesis as well as activation of ERK and JNK mitogen- activated protein kinases, and cell apoptosis. Molecular events of apoptosis including degradation of chromosomal DNA , decrease in the level of Bcl-xL, the disruption of mitochondrial membrane, cytosolic release of cytochrome c and activation of caspase-3 were elucidated. The ability of GAX to inhibit topoisomerases and to sensitize the cancer cells toward apoptosis fulfills the feature of a potential anticancer drug. |
| Relation: | LIFE SCIENCES v.77 n.3 pp.252-265 |
| Appears in Collections: | [醫學檢驗暨生物技術學系] 期刊論文
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