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http://ntur.lib.ntu.edu.tw/handle/246246/94506
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| Title: | Inhibition of Intestinal Glucose Uptake by Aporphines and Secoaporphines |
| Authors: | 林君榮;陳佳壕;劉福文;康照洲;陳建光;李淑玲;李水盛
LIN, CHUN-JUNG;CHEN, CHIA-HAO;LIU, FU-WEN;KANG, JAW-JOU;CHEN, CHIEN-KUANG;LEE, SU-LIN;LEE, SHOEI-SHENG |
| Contributors: | 藥學系 |
| Keywords: | aporphines;secoaporphines;BBMV;BLMV;glucose uptake;glucose tolerance test |
| Date: | 2006 |
| Issue Date: | 2009-09-23T04:32:52Z |
| Abstract: | The effects of aporphines and secoaporphines on glucose uptake by isolated intestinal brush-border membrane vesicles (BBMV) or basolateral membrane vesicles (BLMV) and glucose absorption during in situ intestinal perfusion were studied. Of the tested compounds, N-allylsecoboldine was the most potent glucose uptake inhibitor, with IC50 values of 159 microM and 121 microM, respectively, for uptake by BBMV and BLMV. While thaliporphine competitively inhibited glucose uptake by both membrane preparations, inhibition by N- allylsecoboldine was competitive using BBMV and noncompetitive using BLMV. In addition, N-allylsecoboldine significantly reduced both glucose absorption during in situ intestinal perfusion and blood glucose levels in the oral glucose tolerance test. The results demonstrate that levels of both aporphines and secoaporphines achievable by oral administration have an inhibitory effect on intestinal glucose uptake and suggest that the hypoglycemic effects of these compounds merit attention. |
| Relation: | LIFE SCIENCES v.79 n.2 pp.144-153 |
| Appears in Collections: | [藥學系暨研究所] 期刊論文
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