Loading...
|
Please use this identifier to cite or link to this item:
http://ntur.lib.ntu.edu.tw/handle/246246/93128
|
| Title: | The Vegf-C/Flt-4 Axis Promotes Invasion and Metastasis of Cancer Cells |
| Authors: | 蘇仁亮;楊泮池;施金元;楊卿堯;魏凌鴻;謝長堯;周佳宏;鄭永銘;王明暘;張金堅;郭明良
SU, JEN-LIANG;YANG, PAN-CHYR;SHIH, JIN- YUAN;YANG, CHING-YAO;WEI, LIN-HUNG;HSIEH, CHANG-YAO;CHOU, CHIA-HUNG;JENG, YUNG-MING;WANG, MING-YANG;CHANG, KING-JEN;KUO, MIN-LIANG |
| Contributors: | 內科 |
| Keywords: | Adenocarcinoma/metabolism/ pathology;Animals;Cell Adhesion Molecules, Neuronal/metabolism;Cell Movement;Female;Humans |
| Date: | 2006 |
| Issue Date: | 2009-09-29T04:57:13Z |
| Abstract: | Flt-4, a VEGF receptor, is activated by its specific ligand, VEGF-C. The resultant signaling pathway promotes angiogenesis and/or lymphangiogenesis . This report provides evidence that the VEGF-C/Flt-4 axis enhances cancer cell mobility and invasiveness and contributes to the promotion of cancer cell metastasis. VEGF-C/Flt-4-mediated invasion and metastasis of cancer cells were found to require upregulation of the neural cell adhesion molecule contactin- 1 through activation of the Src-p38 MAPK-C/EBP- dependent pathway. Examination of tumor tissues from various types of cancers revealed high levels of Flt-4 and VEGF-C expression that correlated closely with clinical metastasis and patient survival. The VEGF -C/Flt-4 axis, through upregulation of contactin-1, may regulate the invasive capacity in different types of cancer cells. |
| Relation: | CANCER CELL v.9 n.3 pp.209-223 |
| Appears in Collections: | [醫學系內科] 期刊論文
|
Files in This Item:
There are no files associated with this item.
|
All items in NTUR are protected by copyright, with all rights reserved.
|
