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http://ntur.lib.ntu.edu.tw/handle/246246/87796
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| Title: | Clonal Spread of Sccmec Type Iv Methicillin-Resistant Staphylococcus Aureus between Community and Hospital |
| Authors: | 黃聿玄;曾嵩斌;胡俊民;蔡瑞章;薛博仁;鄧麗珍
HUANG, YU-HSUAN;TSENG, SUNG-PIN;HU, JUN-MIN;TSAI, JUI-CHANG;HSUEH, PO-REN;TENG, LEE-JENE |
| Contributors: | 光電生物醫學研究中心 |
| Keywords: | community-acquired;epidemiology;multilocus sequence typing;MRSA;pulsed-field gel electrophoresis;SCCmec type |
| Date: | 2007 |
| Issue Date: | 2008-12-05T01:01:03Z |
| Abstract: | The staphylococcal chromosome cassette (SCC)mec types of 382 hospital- acquired methicillin-resistant Staphylococcus aureus (HA-MRSA) isolates in Taiwan were analysed over a 7- year period (1999-2005). There was an abrupt increase in SCCmec type IV in HA-MRSA during 2005. The molecular epidemiology of a subset (n = 69) of HA-MRSA isolates with SCCmec types III, IV or V was characterised and compared with that of community- acquired MRSA (CA-MRSA) (n = 26, collected during 2005). Pulsed-field gel electrophoresis revealed three major pulsotypes (A, B and C) and 15 minor clones. Pulsotypes B and C, which contained isolates carrying SCCmec types IV and V, respectively, included both CA-MRSA and HA-MRSA isolates. Among 24 toxin genes analysed, five genes had significant differential distribution between CA-MRSA and SCCmec type III HA-MRSA. Furthermore, among SCCmec type IV isolates, the seb gene was detected more commonly in HA-MRSA. Analysis of representative members of the three major pulsotypes by multilocus sequence typing revealed two sequence types (STs), namely ST 239 (SCCmecIII) and ST59 (SCCmecIV or SCCmecV). This suggests that ST59: SCCmecIV, which is usually community-acquired, has become an important nosocomial pathogen in the hospital studied. |
| Relation: | CLINICAL MICROBIOLOGY AND INFECTION v.13 n.7 pp.717-724 |
| Appears in Collections: | [Center for Optoelectronic Biomedicine] Periodical Articles
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