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http://ntur.lib.ntu.edu.tw/handle/246246/86136
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| Title: | Triflavin, an Arg-Gly-Asp-Containing Antiplatelet Peptide Inhibits Cell- Substratum Adhesion and Melanoma Cell-Induced Lung Colonization |
| Authors: | SHEU, JOEN-RONG;LIN, CHAO-HSINE;CHUNG, JIH-LUAN;TENG, CHE-MING;HUANG, TUR-FU
許準榕;林昭信;鍾紀鑾;鄧哲明;黃德富 |
| Contributors: | 動物中心 |
| Keywords: | RGD-CONTAINING PEPTIDE,TUMOR CELL METASTASIS,EXTRACELLULAR;MATRIX |
| Date: | 1992 |
| Issue Date: | 2008-11-10 |
| Abstract: | Triflavin, an Arg-Gly-Asp (RGD) containing peptide purified from Trimeresurus flavoviridis snake venom, inhibits human platelet aggregation by blocking fibrinogen binding to fibrinogen receptors associated with glycoprotein IIb/IIIa complex. In this study, we show that triflavin (1-30 micrograms/mouse) inhibits B16-F10 melanoma cell-induced lung colonization in C57BL/6 mice in a dose-dependent manner . In vitro, triflavin dose-dependently inhibits adhesion of B16-F10 melanoma cells to extracellular matrices (ECMs; i.e. , fibronectin, fibrinogen, vitronectin, and collagen type I) . Triflavin is approximately 600-800 times more potent than GRGDS at inhibiting cell adhesion. In addition, triflavin dose -dependently inhibits B16-F10 cell-induced platelet aggregation. These results imply that the inhibitory effect of triflavin on the adhesion of tumor cells to ECMs (e.g., fibronectin, vitronectin and collagen type I) and/or tumor cell-induced platelet aggregation may be partially responsible for its antimetastatic activity in C57BL/6 mice. |
| Relation: | JAPANESE JOURNAL OF CANCER RESEARCH v.83 n.8 pp.885-893 |
| Appears in Collections: | [實驗動物中心] 期刊論文
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