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Please use this identifier to cite or link to this item:
http://ntur.lib.ntu.edu.tw/handle/246246/2006111501254611
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| Title: | Genetic polymorphisms in CYP1A1 and GSTM1
predispose humans to PCBs/PCDFs-induced skin lesions |
| Authors: | Tsai, Pei-Chien;Huang, Wenya;Lee, Yeu-Chin;Chan, Shih-Huang;Guo, Yueliang-Leon |
| Contributors: | Department of Environmental and Occupational Medicine, National Taiwan University Medical College |
| Keywords: | Polychlorinated biphenyls;Polychlorinated dibenzofurans;Chloracne;Skin allergy;Single nucleotide polymorphism |
| Date: | 2006 |
| Issue Date: | 2006-11-15 |
| Abstract: | Introduction:Polychlorinated biphenyls (PCBs)and dibenzofurans (PCDFs)are ubiquitous persistent pollutants in
humans.Whether people with di fferent genotypes are with di fferent susceptibility to these chemicals are unknown.In a
group of people highly exposed to PCBs/PCDFs,we tested the hypothesis that genotypic polymorphisms a ffected sus-
ceptibility for development of skin manifestations.
Methods:In 1979,approximately 2000 people in central Taiwan ingested cooking oil contaminated with PCBs/
PCDFs.Skin disorder such as chloracne,abnormal nail,hyperkeratosis and skin allergy were found in PCBs/PCDFs
exposed group.We recruited exposed and community background exposure subjects for blood testing and telephone-
interview.Single nucleotide polymorphisms,AhR Arg554Lys,CYP1A1 Ile462Val,CYP1A1 T6235C,and GSTM1/T1
deletion,were determined.Occurrence of skin manifestations was compared among people with di fferent genotypes
while strati fied by PCB exposure levels by logistic regression.
Results:Data on exposure,medical history,and genotypes were obtained from 393 exposed and 181 background
exposure groups.Skin manifestations including chloracne,allergy,abnormal nail,and hyperkeratosis were more pre-
valent in exposed people in a dose-related manner.Among highly exposed individuals,combined CYP1A1-MspI
mutant genotype and GSTM1-null genotype were associated with increased risk of chloracne (odds ratio 2.8,95%con-
fidence interval 1.1 –7.6).Among intermediately exposed individuals,GSTM1 null genotype was associated with skin
allergy.AhR Arg554Lys genotype and GSTT1 null genotype were not related to susceptibility to skin manifestations
in PCB/PCDF-exposed population.
Conclusion:CYP1A1 and GSTM1 genotypic polymorphisms might be related to the susceptibility to PCB/PCDF-
induced skin manifestations. |
| Relation: | Chemosphere 63,1410-1418 |
| Appears in Collections: | [醫學院] 期刊論文
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