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Please use this identifier to cite or link to this item:
http://ntur.lib.ntu.edu.tw/handle/246246/2006111501222772
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| Title: | Ganoderic acid X, a lanostanoid triterpene, inhibits topoisomerases
and induces apoptosis of cancer cells |
| Authors: | Li, Chyi-Hann;Chen, Pei-Yu;Chang, Ue-Min;Kan, Lou-Sing;Fang, Woei-Horng;Tsai, Keh-Sung;Lin, Shwu-Bin |
| Contributors: | National Taiwan University Coll Med |
| Keywords: | Ganoderma triterpene;Ganoderic acid X;Apoptosis;Topoisomerase inhibitor |
| Date: | 2005 |
| Issue Date: | 2006-11-15 |
| Abstract: | Lanostanoid triterpenes isolated from Ganoderma amboinense were found to inhibit the growth of numerous
cancer cell lines, and some of them inhibited the activities of topoisomerases I and IIa in vitro. Among the
bioactive isolates, one of the most potent triterpene was identified to be 3a-hydroxy-15a-acetoxy-lanosta-7,9(
11),24-trien-26-oic acid, ganoderic acid X (GAX). Treatment of human hepatoma HuH-7 cells with GAX
caused immediate inhibition of DNA synthesis as well as activation of ERK and JNK mitogen-activated protein
kinases, and cell apoptosis. Molecular events of apoptosis including degradation of chromosomal DNA, decrease
in the level of Bcl-xL, the disruption of mitochondrial membrane, cytosolic release of cytochrome c and activation
of caspase-3 were elucidated. The ability of GAX to inhibit topoisomerases and to sensitize the cancer cells toward
apoptosis fulfills the feature of a potential anticancer drug. |
| Relation: | Life Sciences 77,252-265 |
| Appears in Collections: | [醫學院] 期刊論文
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| 3259.pdf | | 370Kb | Adobe PDF | 119 | View/Open |
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