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Please use this identifier to cite or link to this item:
http://ntur.lib.ntu.edu.tw/handle/246246/2006111501211800
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| Title: | CD94 1A transcripts characterize lymphoblastic lymphoma/leukemia of immature natural killer cell origin with distinct clinical features |
| Authors: | Lin, Chung-Wu;Liu, Ting-Yun;Chen, Shee-Uan;Wang, Kun-Teng;Medeiros, L. Jeffrey;Hsu, Su-Ming |
| Contributors: | National Taiwan University College of Medicine |
| Date: | 2005 |
| Issue Date: | 2006-11-15 |
| Abstract: | Most lymphoblastic lymphomas (LBLs)
are regarded as neoplasms of immature T
cells because they express cytoplasmic
CD3 and frequently carry T-cell receptor
(TCR) gene rearrangements. Immature
natural killer (NK) and T cells, however,
have a common bipotent T/NK-cell precur-sor
in the thymus, and NK cells also
express cytoplasmic CD3. Thus, some
LBLs could arise from immature NK cells.
Mature NK cells express 2 CD94 tran-scripts:
1A, induced by interleukin 15
(IL-15), and 1B constitutively. Because
immature NK cells require IL-15 for devel-opment,
CD94 1A transcripts could be a
marker of NK-LBL. To test this hypoth-esis,
we used laser capture microdissec-tion
to isolate IL-15 receptor lymphoid
cells from the thymus and showed that
these cells contained CD94 1A tran-scripts.
We then assessed for CD94 tran-scripts
in 21 cases of LBL that were
cytoplasmic CD3 , nuclear terminal de-oxynucleotidyl
transferase positive
(TdT ), and CD56 , consistent with either
the T-cell or NK-cell lineage. We found
that 7 LBLs expressed CD94 1A tran-scripts
without TCR gene rearrange-ments,
suggesting NK-cell lineage. Pa-tients
with NK-LBL were younger than
patients with T-LBL (15 years versus 33
years; P .11) and had a better 2-year
survival (100% versus 27%; P < .01).
These results improve the current classi-fication
of LBL and contribute to our
understanding of NK-cell differentiation. |
| Relation: | BLOOD 106(10),3567-3574 |
| Appears in Collections: | [醫學院] 期刊論文
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