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Please use this identifier to cite or link to this item:
http://140.112.114.62/handle/246246/171542
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| Title: | Effect of Intracameral Injection of Lidocaine and Carbachol on the Rabbit Corneal Endothelium |
| Authors: | 劉秀雯;王一中
LIOU, SHIOW-WEN;WANG, I-JONG |
| Contributors: | 眼科部 |
| Date: | 2004 |
| Issue Date: | 2009-10-21T10:54:13Z
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| Abstract: | Purpose: To determine the effect of intracameral injection of preservative-free lidocaine 1% and carbachol 0.01% on corneal endothelial cells of rabbits. Setting: Department of Ophthalmology, National Taiwan University Hospital, Taipei, Taiwan. Methods: Forty eyes of 20 New Zealand White rabbits were divided into 2 equal groups. In the first group, 1 eye was injected with 0.02 mL of preservative-free lidocaine 1% and the fellow eye was injected with 0.02 mL of normal saline as a control. In the second group, 1 eye was injected with 0.02 mL of carbachol 0.01% and the fellow eye was injected with 0.02 mL of normal saline. Specular microscopy was used to evaluate corneal endothelial cell loss and corneal thickness 1 week and 1 month postinjection. For morphologic studies, corneal buttons were excised and stained with alizarin red with trypan blue. Scanning electron microscopy (SEM) examination was performed. Results . Specular microscopy revealed no significant endothelial cell loss and normal endothelial thickness with the intracameral injection of preservative-free lidocaine 1% and carbachol 0.01% compared with the control eye. Alizarin red with trypan blue stain and SEM examinations revealed smooth , distinct , and intact intercellular borders and normal viability of corneal endothelial cells in both groups. Conclusions. Intracameral injections of preservative-free lidocaine 1% and carbachol 0.01% do not produce morphologic and functional changes in the corneal endothelial cells of rabbits. |
| Relation: | JOURNAL OF CATARACT AND REFRACTIVE SURGERY v.30 n.6 pp.1351-1355 |
| Appears in Collections: | [ ] Peridocal Articles
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