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http://140.112.114.62/handle/246246/171151
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| 题名: | A Comparison of the Effect of Carbomer-, Cellulose-, and Mineral Oil- Based Artificial Tear Formulations |
| 作者: | 王一中;林怡嬋;侯育致;胡芳蓉
WANG, I-JONG;LIN, I-CHAN;HOU, YU-CHIH;HU, FUNG-RONG |
| 贡献者: | 眼科部 |
| 日期: | 2007 |
| 上传时间: | 2009-10-21T06:32:47Z
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| 摘要: | PURPOSE: To compare the efficacy, safety, and local tolerance between carbomer-based artificial tears, cellulose -, and mineral oil-based artificial tears. METHODS: A randomized, open-label, parallel-group comparative 28-day study was designed for 67 patients who were randomized into three treatment groups. Measurements included the scoring of total subjective symptoms and objective signs, Schirmer- Jones test values, and tear break-up time (BUT) at baseline, and after 2 and 4 weeks of treatment . Safety of study treatment was also assessed. Outcomes measured at baseline and 2 and 4 weeks follow-up included the scoring of total subjective symptoms and objective signs, Schirmer-Jones test values, and tear BUT, subjective assessments, and safety. RESULTS: There were no differences regarding total scores, Schirmer-Jones test, or tear BUT at baseline among these three groups at 2 and 4 weeks. Patients in all three treatment groups experienced a significant improvement from baseline in total scores and Schirmer-Jones test values after treatment. Subjective assessment was better with carbomer-based treatment. CONCLUSIONS: Each artificial tear formulation successfully relieved symptoms and signs of keratoconjunctivitis sicca. The tolerance of carbomer-based artificial tears was comparable to that of cellulose- and mineral oil-based artificial tears. subjective symptoms and objective signs, Schirmer-Jones test values, and tear BUT, subjective assessments, and safety. |
| 關聯: | EUROPEAN JOURNAL OF OPHTHALMOLOGY v.17 n.2 pp.151-159 |
| 显示于类别: | [附設醫院眼科部] 期刊論文
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