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http://ntur.lib.ntu.edu.tw/handle/246246/170413
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| Title: | Intra-Thoracic Failure Pattern and Survival Status Following 3d Conformal Radiotherapy for Non-Small Cell Lung Cancer: A Preliminary Report |
| Authors: | 簡君儒;謝長堯;黃昭源
CHIEN, CHUN-RU;HSIEH, CHANG-YAO;HUANG, CHAO-YUAN |
| Contributors: | 腫瘤醫學部 |
| Date: | 2001 |
| Issue Date: | 2009-10-13T15:06:58Z |
| Abstract: | Background: To study the intra-thoracic failure pattern, clinical target volume (CTV) and survival status following 3 D conformal radiotherapy (3 DCRT) boost for non-small cell lung cancer (NSCLC). Methods: From May 1994 through June 1998, 33 patients (26 male, seven female) with NSCLC were treated with a complete course of radiotherapy (RT) in our institute. Group A included 10 patients receiving radical operation and adjuvant postoperative RT. The other 23 patients (groups B and C) received definitive radiotherapy as local treatment. Among them there were seven cases as group B (stage I-II) and 16 cases as group C (stage III). Fifteen (15/33) patients received chemotherapy. The radiotherapy strategy constituted conventional AP/PA radiotherapy (RT) 19.8-45 Gy (median 39.6 Gy) plus 3DCRT boost 6-34.2 Gy (median 20 Gy). The median total tumor dose was 59.6 Gy (ranging from 39.8 to 64.8 Gy). Patients were followed up regularly (6/33) or until their death (27/33). Nineteen patients received follow-up chest computed tomography (CT). The relationship between intra- thoracic failure found by chest CT and the initial RT and boost RT fields was analyzed. Local failure was defined as one of the following: clinical disease progression, CXR progression or relapse noted by CT. The overall survival (OS) and local failure free survival (LFF) were obtained using the Kaplan- Meier method. Results: Sixteen intra-thoracic failures were noted in 15 follow-up chest CT examinations, which included nine in-field relapses, three partial in-field relapses and four out-field relapses. The 2-year OS and LFF for groups A, B and C were 78.8/59.2, 14.2/16.7 and 6.2 /7.1% respectively . RTOG grade III/IV complications included one pneumothorax (RTOG grade III). Conclusion: Our retrospective study showed that selective omission of contralateral mediastinal lymph node station irradiation may be appropriate in RT for NSCLC. Chest wall and pleural relapses may not be a negligible cause of intra-thoracic failure after RT for NSCLC. |
| Relation: | JAPANESE JOURNAL OF CLINICAL ONCOLOGY v.31 n.2 pp.55-60 |
| Appears in Collections: | [附設醫院腫瘤醫學部] 期刊論文
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