Loading...
|
Please use this identifier to cite or link to this item:
http://ntur.lib.ntu.edu.tw/handle/246246/169126
|
| Title: | Attenuated Response of Renal Mechanoreceptors to Volume Expansion in Chronically Hypoxic Rats
長期缺氧鼠腎機械接受器對體液擴張之遲緩反應 |
| Authors: | 鄭劍廷;傅祖慶;吳明修;陳朝峰
CHIEN, CHIANG-TING;FU, TSU-CHING;WU, MING-SHIOU;CHEN, CHAU-FONG |
| Contributors: | 醫學研究部 |
| Date: | 1997 |
| Issue Date: | 2009-09-30T07:38:06Z |
| Abstract: | Multifiber renal afferent nerve activity responds to volume expansion in sea level rats but not in chronically hypoxic (high altitude) rats. We performed single-unit recordings of renal afferent nerve activity to characterize renal sensory receptors and their responses to volume expansion in these animals. Hypoxia was induced by placing Wistar rats in an altitude chamber (380 Torr, 5,500 m) for 4 wk. Spontaneously firing renal R2 chemoreceptor and arterial, ureteropelvic, and venous mechanoreceptors were identified. The basal activity of each receptor was similar among these rats. In esponse to specific stimulus, the increasing impulse of R2 chemoreceptor was similar between two groups of rats, but the increasing activity of each mechanoreceptor was less in hypoxic rats. When challenged with saline load, R2 chemoreceptor activity decreased, but all mechanoreceptors activated in all rats. Despite similar increases of arterial, renal ureteropelvic, and venous pressure during saline load, the increasing activity of each mechanoreceptor was significantly less in hypoxic rats. These results indicated chronic hypoxia attenuates the sensi-tivity of renal mechanoreceptors in response to the stimula-tion of saline load. |
| Relation: | AMERICAN JOURNAL OF PHYSIOLOGY v.273 n.42 pp.F712-F717 |
| Appears in Collections: | [附設醫院醫學研究部] 期刊論文
|
Files in This Item:
There are no files associated with this item.
|
All items in NTUR are protected by copyright, with all rights reserved.
|
