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http://ntur.lib.ntu.edu.tw/handle/246246/169124
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| Title: | Ischemic Renal Failure in Chronic Hypoxic Rats |
| Authors: | 鄭劍廷;陳朝峰
CHIEN, CHIANG-TING;CHEN, CHAU-FONG |
| Contributors: | 醫學研究部 |
| Date: | 1994 |
| Issue Date: | 2009-09-30T07:36:29Z |
| Abstract: | The after effects of renal ischemia were studied in hypoxia-adapted rats. It was felt that chronic hypoxia animals which had already adapted to a low oxygen level might be more tolerant of renal ischemic insult; however, chronic hypoxia is always accompanied by polycythemia, which may cause severe RBC trapping and consequently might enhance renal damage after renal ischemia. Chronic hypoxic rats were prepared by exposure in an altitude chamber 15 h per day for 4 weeks. The plasma sodium, potassium, urea, and creatinine levels were determined to compare the changers in these parameters between the baseline and 3 h after a 45- min occlusion of both renal arteries in 12 sea-level (SLB) controls and in 12 chronic hypoxic (CHB) and 11 chronic hypoxic plus RBC pheresis (to reduce gematocrit:CH+P) rats. From the parameters measured, the CHB rats were found to be more tolerant of reanal ischemia. However, this was not the case in the rats with pheresis. It is concluded that after chronic hypoxia , some humoral factors in the plasma may play an important role in reducing the renal damage after ischemic insult. |
| Relation: | RENAL FAILURE v.16 n.2 pp.255-261 |
| Appears in Collections: | [附設醫院醫學研究部] 期刊論文
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