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http://ntur.lib.ntu.edu.tw/handle/246246/169113
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| Title: | Temporal Changes in Cytokine/Chemokine Profiles and Pulmonary Involvement in Severe Acute Respiratory Syndrome |
| Authors: | 簡榮彥;薛博仁;鄭文誠;余忠仁;楊泮池
CHIEN, JUNG-YIEN;HSUEH, PO-REN;CHENG, WERN-CHERNG;YU, CHONG-JEN;YANG, PAN-CHYR |
| Contributors: | 雲林分院 |
| Date: | 2006 |
| Issue Date: | 2009-09-30T07:27:05Z |
| Abstract: | Objective and background: Pathological changes in severe acute respiratory syndrome (SARS) suggest that SARS sequelae are associated with dysregulation of cytokine and chemokine production. To improve understanding of the immuno- pathological processes involved in lung injury associated with SARS, the temporal changes in cytokine/chemokine profiles in the sera of SARS patients were compared with those of patients with community-acquired pneumonia (CAP), according to the degree of lung involvement. Methods: Serum levels of 11 cytokines and chemokines, in 14 patients with SARS and 24 patients with CAP, were serially checked using a bead-based multiassay system. Sera from 12 healthy subjects were used as normal controls. Results: The serum levels of interferon-gamma-inducible protein-10 (IP-10), IL-2 and IL-6 were significantly elevated during SARS infection. In patients with CAP, but not in those with SARS, the levels of interferon-gamma, IL-10, IL-8 and monokine induced by interferon-gamma ( MIG) were significantly elevated compared with the levels in healthy controls. Among the chemokines/ cytokines, IL-6 levels correlated most strongly with radiographic scores (r = 0.62). The elevation of IP-10 and IL-2 antedated the development of chest involvement and reached peak levels earlier than the radiographic scores. In contrast, the dynamic changes in IL-6, C-reactive protein and neutrophils occurred synchronously with the changes in radiographic scores. The mean ratio of IL-6 to IL-10 in SARS patients (4.84; range 0.41-21) was significantly higher than that in CAP patients (2.95; range 0.02-10.57) (P = 0.04 ). Conclusions: The early induction of IP-10 and IL-2, as well as the subsequent over- production of IL-6 and lack of IL-10 production, probably contribute to the main immuno- pathological processes involved in lung injury in SARS. These changes in cytokine/chemokine profile are remarkably different from those observed in CAP patients. |
| Relation: | RESPIROLOGY v.11 n.6 pp.715-722 |
| Appears in Collections: | [ ] Periodical Articles
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