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http://ntur.lib.ntu.edu.tw/handle/246246/169102
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| 题名: | The Effects of Metabolic Syndrome Versus Infectious Burden on Inflammation, Severity of Coronary Atherosclerosis, and Major Adverse Cardiovascular Events |
| 作者: | 戴道福;林昭維;高嘉宏;許智能;江福田;林俊立;許寬立;曾春典;曾淵如;黃瑞仁
DAI, DAO-FU;LIN, JOU-WEI;KAO, JIA-HORNG;HSU, CHIH-NENG;CHIANG, FU-TIEN;LIN, JIUNN-LEE;HSU, KWAN-LIH;TSENG, CHUEN-DEN;TSENG, YUNG-ZU;HWANG, JUEY-JEN |
| 贡献者: | 雲林分院 |
| 日期: | 2007 |
| 上传时间: | 2009-09-30T07:18:40Z |
| 摘要: | Background: The clinical predictors of inflammation in atherosclerosis remain controversial. The objective of this study was to compare the associations of metabolic factors vs. infectious burden (IB) with inflammation, the severity of coronary atherosclerosis, and major adverse cardiovascular events (MACEs). Design, Setting, and Patients : Coronary angiography with Gensini score was applied to assess the severity of coronary atherosclerosis in 568 patients with coronary artery disease. Metabolic syndrome ( MS) score (0–5) was defined according to the modified criteria of National Cholesterol Education Program Adult Treatment Panel III. IB score (0–7) was defined as the number of seropositivities to several agents. Results: IB score was not associated with plasma C-reactive protein (CRP ) concentration, Gensini score, or the risk of MACE. In contrast, MS score significantly correlated with both plasma CRP concentration and Gensini score (P < 0.001 for both). MS score and plasma CRP concentration were also significantly associated with the risk of MACE (hazard ratios 1.51, P < 0.001; and 1.90, P = 0.002, respectively). Conclusion: Compared with IB, metabolic abnormalities have a more prominent association with the degree of inflammation, the severity of coronary atherosclerosis, and the risk of MACE in patients with coronary artery disease. |
| 關聯: | JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM v.92 n.7 pp.2532-2537 |
| 显示于类别: | [附設醫院雲林分院] 期刊論文
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