Loading...
|
Please use this identifier to cite or link to this item:
http://140.112.114.62/handle/246246/169098
|
| Title: | In Vitro Maturation Potential of Monocyte-Derived Dendritic Cells Is Impaired in Patients with Spinal Cord Injury: A Case-Control Study |
| Authors: | 盤松青;謝思民;王顏和;江伯倫;黃天祥;張上淳
PAN, SUNG-CHING;HSIEH, SZU-MIN;WANG, YEN-HO;CHIANG, BOR-LUEN;HUANG, TIEN-SHANG;CHANG, SHAN-CHWEN |
| Contributors: | 雲林分院 |
| Date: | 2005 |
| Issue Date: | 2009-09-30T07:16:36Z
|
| Abstract: | Objective To determine whether the T-cell reactivity and maturation potential of dendritic cells are impaired in subjects with spinal cord injury (SCI). Design Cross- sectional, case-control study. Setting University hospital in Taiwan. Participants Thirty male SCI subjects, including 14 with paraplegia and 16 with tetraplegia, and 30 age- and sex- matched healthy controls. Interventions Not applicable. Main outcome measures CD4+ and CD8+ T-cell reactivity was assessed by lymphoproliferative response (LPR) and CD69 expression in response to stimulation with antigens, anti-CD 3 monoclonal antibody, and mitogen. Dendritic cell maturation potential was assessed by phenotypic (CD80 and CD 83 expression in stimulated monocyte-derived dendritic cells) and functional (the LPR of alloreactive T cells in mixed leukocyte reactions) analysis. Results The potential of phenotypic and functional maturation of dendritic cells of subjects with SCI was significantly impaired compared with healthy controls, and that potential was worse for tetraplegic patients than for paraplegic patients. However, no significant difference was found in T-cell responses of CD4+ and CD8+ subsets between subjects with SCI and healthy controls. Conclusions Impaired maturation potential of dendritic cells is a novel defect in innate immunity in people with SCI . |
| Relation: | ARCHIVES OF PHYSICAL MEDICINE AND REHABILITATION v.86 n.5 pp.974-978 |
| Appears in Collections: | [附設醫院雲林分院] 期刊論文
|
Files in This Item:
There are no files associated with this item.
|
All items in NTUR are protected by copyright, with all rights reserved.
|
