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| Title: | Placental Growth Factor down-Regulates Type 1 T Helper Immune Response by Modulating the Function of Dendritic Cells.
胎盤生長因子藉由調節數突狀細胞的功能來抑制th1免疫反應 |
| Authors: | 林郁里;梁有志;江伯倫
LIN, YU-LI;LIANG, YU-CHIH;CHIANG, BOR-LUEN |
| Contributors: | 醫學研究部 |
| Date: | 2007 |
| Issue Date: | 2009-09-30T06:49:08Z |
| Abstract: | Placental growth factor (PlGF) belongs to the vascular endothelial growth factor (VEGF) family and represents a key regulator of angiogenic events in development and pathologic conditions. In this study, PlGF-modulated differentiation and maturation of human dendritic cells (DCs ) from CD14 from CD14 of PlGF during 5 days, was referred to as“PlGF-DC”,in contrast to the “classical-DC”, obtained in the absence of PlGF. Treatment of PlGF-DC or classical- DC with PlGF resulted in the down-regulation of CD80 , CD86, CD83, CD40, and HLA-DR expression, and CD1a was increased, as well as the inhibition of IL-12 p70, p40, IL-8, and TNF- This PlGF-induced DC dysfunction was recovered by anti-human VEGF receptor 1 mAb. In addition, treatment of PlGF-DC or classical-DC with PlGF resulted in the suppression of na&# 305;¨ve CD4 up-regulated the IL-5 and IL-13 secretion of the CD4 I B Taken together, our data demonstrate that the immunosuppressive properties of PlGF are through the NF- B signaling pathway. PlGF might play a major role in the pathogenesis of tumors and act as an effector molecule to skew T cell response to the Th2 phenotype, which might be more beneficial for pregnancy. |
| Relation: | JOURNAL OF LEUKOCYTE BIOLOGY v.82 n.6 pp.1473-1480 |
| Appears in Collections: | [附設醫院醫學研究部] Periodical Articles
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