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| Title: | Osteonecrosis in Patients with Human Immunodeficiency Virus Type 1 Infection in Taiwan |
| Authors: | 何雅琦;施庭芳;蕭金福;陳茂源;謝思民;盛望徽;孫幸筠;洪健清;張上淳
HO, YA-CHI;SHIH, TIFFANY TING-FANG;HSIAO, CHIN-FU;CHEN, MAO-YUAN;HSIEH, SZU-MIN;SHENG, WANG-HUEI;SUN, HSIN-YUN;HUNG, CHIEN-CHING;CHANG, SHAN-CHWEN |
| Contributors: | 雲林分院 |
| Date: | 2007 |
| Issue Date: | 2009-09-30T06:17:32Z |
| Abstract: | Osteonecrosis, a disabling complication associated with antiretroviral therapy (ART) and human immunodeficiency virus (HIV) infection, has rarely been reported in an Asian population. After an observation of 3,250 person-years (PY), 11 of 967 (1.1%) HIV-infected patients at a median age of 34 years developed osteonecrosis involving the hip joints ( incidence, 3.4 per 1,000 PY). Their median CD4+ lymphocyte count had increased from 35 cells/mu L at the diagnosis of HIV infection to 297 cells/mu L at the diagnosis of osteonecrosis. The crude rate of osteonecrosis increased from 0% in patients without exposure to ART to 2.6 and 1.7% in patients with exposure to nucleoside reverse transcriptase inhibitors (NRTIs) and who had undergone highly active antiretroviral therapy (HAART) for 5 years or longer, respectively (P = 0.18 and 0.09, respectively). Among the patients receiving HAART, the estimated incidence of osteonecrosis was 4.2 per 1, 000 PY. Patients with osteonecrosis had a longer duration of exposure to NRTIs (1, 641 versus 1,264 days, P = 0.26) and to HAART (1,603 versus 1, 251 days, P = 0.42), a higher serum triglyceride (median, 1, 130 versus 3 51 mg/dl; P = 0.09), and a higher proportion of lipodystrophy (81.8 versus 15.0%, P < 0.000 1) . Our report suggests that osteonecrosis is a rare complication in HIV-infected patients with prolonged exposure to ART with resultant metabolic complications. |
| Relation: | JAPANESE JOURNAL OF INFECTIOUS DISEASES v.60 n.6 pp.382-386 |
| Appears in Collections: | [ ] Periodical Articles
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