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http://ntur.lib.ntu.edu.tw/handle/246246/168920
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| Title: | An Immunocompetent Mouse Model for the Tolerance of Human Chronic Hepatitis B Virus Infection |
| Authors: | 黃麗蓉;吳慧琳;陳培哲;陳定信
HUANG, LI-RUNG;WU, HUI-LIN;CHEN, PEI-JER;CHEN, DING-SHINN |
| Contributors: | 肝炎研究中心 |
| Date: | 2006 |
| Issue Date: | 2009-09-29T08:32:13Z |
| Abstract: | An animal model for human hepatitis B virus (HBV) tolerance is needed to investigate the mechanisms. This model will also facilitate therapeutic strategies for the existing 350 million patients with chronic hepatitis B. We established a mouse model by hydrodynamic injection of an engineered, replication-competent HBV DNA into the tail veins of C57BL/6 mice. In 40% of the injected mice, HBV surface antigenemia persisted for > 6 months. Viral replication intermediates, transcripts, and proteins were detected in the liver tissues of the injected mice for up to 1 year. The tolerance toward HBV surface antigen in this model was shown to be due to an insufficient cellular immunity against hepatitis B core antigen, as was documented in humans. This animal model will accelerate further genetic and mechanistic studies of human chronic hepatitis B infection. |
| Relation: | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA v.103 n.47 pp.17862-17867 |
| Appears in Collections: | [附設醫院肝炎研究中心] 期刊論文
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