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http://ntur.lib.ntu.edu.tw/handle/246246/168798
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| Title: | 99mtc-Hl91 Is Inferior to 201tl in Scintigraphic Detection of Chronic Myocardial Ischaemia |
| Authors: | 吳彥雯;李啟明;黃奕琿;周迺寬;顏若芳;曾凱元;黃博昭
WU, YEN-WEN;LEE, CHII-MING;HUANG, YI-HUI;CHOU, NAI-KUAN;YEN, RUOH-FANG;TZEN, KAI-YUAN;HUANG, POR-JAU |
| Contributors: | 核子醫學部 |
| Date: | 2005 |
| Issue Date: | 2009-09-29T07:16:40Z |
| Abstract: | Aim: 99mTc-HL91 is a new hypoxia agent and can identify acutely ischaemic viable myocardium in a canine model using a standard gamma camera. The purpose of the study was to determine whether this tracer could be used to detect regional ischaemia in chronic ischaemic myocardium in a swine model. Method: Using a porcine model of chronic myocardial ischaemia, five mini-pigs with proximal left anterior descending artery (LAD) stenoses were studied. Injection of 462.5 MBq (12.5 mCi) 99mTc-HL91 was followed by imaging over 2 h. Coronary angiography and dipyridamole stress-re- injection 201Tl single photon emission computed tomography (SPECT) were performed within 1 day of each other . Results: None of the five pigs demonstrated positive hot 99mTc-HL91 uptake throughout the 2 h imaging, whereas four of the five animals showed significant myocardial ischaemia on 201Tl SPECT. The region of interest analysis of LAD/left circumflex artery count ratios at 1 and 2 h demonstrated similar 99mTc-HL91 uptake and retention in chronic ischaemic as well as non-ischaemic myocardium. |
| Relation: | NUCLEAR MEDICINE COMMUNICATIONS v.26 n.12 pp.1119-1123 |
| Appears in Collections: | [附設醫院核子醫學部] 期刊論文
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