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http://ntur.lib.ntu.edu.tw/handle/246246/167866
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| Title: | Hypertension Status Is the Major Determinant of Carotid Atherosclerosis - a Community-Based Study in Taiwan |
| Authors: | 蘇大成;鄭建興;簡國龍;宋鴻樟;許秀卿;李源德
SU, TA-CHEN;JENG, JIANN-SHING;CHIEN, KUO-LIONG;SUNG, FUNG-CHANG;HSU, HSIU-CHING;LEE, YUAN-THE |
| Contributors: | 內科部 |
| Date: | 2001 |
| Issue Date: | 2009-09-23T19:31:26Z |
| Abstract: | Background anti Purpose-Extracranial carotid artery (ECCA) atherosclerosis has been associated with hypertension- related stroke. The present study was aimed at investigating the determinants of ECCA atherosclerosis in patients with hypertension in Taiwan. Methods-The extent and severity of ECCA atherosclerosis were measured by high- resolution B-mode ultrasonography and expressed as maximal intima-media thickness (IMT) of the common carotid artery, ECCA plaque score, and carotid stenosis greater than or equal to 50%. From July through December 1996, 263 hypertensive patients ( 146 with hypertension and 117 with borderline hypertension) and 270 normotensive adults from the Chin-Shan Community Cardiovascular Cohort participated in this study. Risk factors and ECCA atherosclerosis were stratified by the blood pressure status. Results-A significant dose-response relationship was found between the status of hypertension and the severity of carotid atherosclerosis. Multivariate logistic regression models revealed that hypertension ( including borderline), male gender, smoking, and age greater than or equal to 65 years significantly increased the risk of thicker MT. The risk of ECCA plaque score >6 increased significantly in conjunction with hypertension, age greater than or equal to 65 years, left ventricular hypertrophy on ECG, and smoking. However, hypertension and smoking were the 2 evident determinants of carotid stenosis greater than or equal to 50 % after adjustment for other covariates. Compared with the normotensive subjects, the ORs (and 95% CIs) for the hypertensive patients to develop carotid atherosclerosis were 5.0 (3.0 to 8.4) indexed by maximal common carotid artery IMT greater than or equal to 75th percentile, 3.7 (1. 8 to 7.9) by ECCA score >6, and 4.8 (1.4 to 16.5) by carotid stenosis greater than or equal to 50%. Conclusions- Hypertension strongly influence carotid atherosclerosis. Our findings reinforce the hypothesis that hypertension has a major role in the pathogenesis of atherosclerosis. |
| Relation: | STROKE v.32 n.10 pp.2265-2271 |
| Appears in Collections: | [ ] Periodical Articles
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