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http://ntur.lib.ntu.edu.tw/handle/246246/166653
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| Title: | Decreased Maternal Serum Placenta Growth Factor in Early Second Trimester and Preeclampsia |
| Authors: | 蘇怡寧;李建南;鄭文芳;周松男;謝豐舟
SU, YI-NING;LEE, CHIEN-NAN;CHENG, WEN-FANG;CHOW, SONG-NAN;HSIEH, FON-JOU |
| Contributors: | 基因醫學部 |
| Date: | 2001 |
| Issue Date: | 2009-09-23T02:50:36Z |
| Abstract: | Objective: To compare early second-trimester maternal serum placenta growth factor concentrations in patients with subsequent development of preeclampsia and those with normal pregnancies.Methods: We conducted a case-control analysis of stored maternal serum of 27 women who subsequently developed preeclampsia and 227 randomly selected normal controls during the gestational period of 14-19 weeks. Using such a sample size, there was a greater than 95% power to test a difference in the primary study interest. A quantitative sandwich enzyme immunoassay was used to measure the maternal serum placenta growth factor concentration. For statistical analysis, Mann-Whitney U tests, multiple linear regression analysis, multivariable logistic regression model, and receiver-operating characteristic (ROC ) curve were used. P < .05 was considered statistically significant.Results: Maternal serum placenta growth factor concentration was associated with the occurrence of subsequent preeclampsia (P < .001) and gestational age (P <. 001). The median ( interquartile range) of multiples (MoM) of the gestational age stratified median for placenta growth factor in preeclampsia was 0.55 (0.33, 0.85). The ROC curve revealed that the specificity was 70% when the diagnostic sensitivity was 70%, and the optimal cutoff value of placenta growth factor MoM was 0.76. The risk of developing preeclampsia subsequently was increased 2.5-fold for maternal serum placenta growth factor concentration decrements of 0.1 MoM.Conclusion: A decreased maternal serum placenta growth factor concentration in the early second trimester is highly associated with the subsequent development of preeclampsia, but a large prospective study is needed to explore its use as an early predictor for the condition. (Obstet Gynecol 2001;97:898-904. (C) 2001 by The American College of Obstetricians and Gynecologists.). |
| Relation: | OBSTETRICS AND GYNECOLOGY v.97 n.6 pp.898-904 |
| Appears in Collections: | [附設醫院基因醫學部] 期刊論文
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